HPLC Method Development for Pharmaceuticals download book

HPLC Method Development for Pharmaceuticals download book

HPLC Method Development for Pharmaceuticals by Satinder Ahuja

HPLC Method Development for Pharmaceuticals
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Author: Satinder Ahuja
Number of Pages: 532 pages
Published Date: 21 Jun 2007
Publisher: Elsevier Science Publishing Co Inc
Publication Country: San Diego, United States
Language: English
ISBN: 9780123705402
File size: 14 Mb
File Name: HPLC.Method.Development.for.Pharmaceuticals.pdf
Download Link: HPLC Method Development for Pharmaceuticals
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High pressure, or high performance, liquid chromatography (HPLC) is the method of choice for checking purity of new drug candidates, monitoring changes during scale up or revision of synthetic procedures, evaluating new formulations, and running control/assurance of the final drug product. "HPLC Method Development for Pharmaceuticals" provides an extensive overview of modern HPLC method development that addresses these unique concerns. It includes a review and update of the current state of the art and science of HPLC, including theory, modes of HPLC, column chemistry, retention mechanisms, chiral separations, modern instrumentation (including ultrahigh-pressure systems), and sample preparation. Emphasis has been placed on implementation in a pharmaceutical setting and on providing a practical perspective. "HPLC Method Development for Pharmaceuticals" is intended to be particularly useful for both novice and experienced HPLC method development chemists in the pharmaceutical industry and for managers who are seeking to update their knowledge. It covers the requirements for HPLC in a pharmaceutical setting including strategies for software and hardware validation to allow for use in a regulated laboratory. It provides an overview of the pharmaceutical development process (clinical phases, chemical and pharmaceutical development activities). It discusses how HPLC is used in each phase of pharmaceutical development and how methods are developed to support activities in each phase.

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